| Santa Margarita to Seymour (Tennessee) | 4,552.87 mi (7,327.13 km) |
| Santa Margarita to Shady Hills (Florida) | 4,780.86 mi (7,694.05 km) |
| Santa Margarita to Shafter (California) | 6,076.05 mi (9,778.45 km) |
| Santa Margarita to Shaker Heights (Ohio) | 4,250.89 mi (6,841.15 km) |
| Santa Margarita to Shakopee (Minnesota) | 4,643.85 mi (7,473.55 km) |
| Santa Margarita to Sharon (Pennsylvania) | 4,211.46 mi (6,777.69 km) |
| Santa Margarita to Sharonville (Ohio) | 4,457.33 mi (7,173.39 km) |
| Santa Margarita to Shasta Lake (California) | 5,910.38 mi (9,511.84 km) |
| Santa Margarita to Shawnee (Kansas) | 4,929.42 mi (7,933.14 km) |
| Santa Margarita to Shawnee (Oklahoma) | 5,177.46 mi (8,332.32 km) |
| Santa Margarita to Sheboygan (Wisconsin) | 4,443.11 mi (7,150.49 km) |
| Santa Margarita to Shelby (North Carolina) | 4,469.18 mi (7,192.45 km) |
| Santa Margarita to Shelbyville (Indiana) | 4,510.32 mi (7,258.66 km) |
| Santa Margarita to Shelbyville (Kentucky) | 4,534.30 mi (7,297.26 km) |
| Santa Margarita to Shelbyville (Tennessee) | 4,693.21 mi (7,552.99 km) |
