| Santa Margarita to Olympia Heights (Florida) | 4,775.68 mi (7,685.72 km) |
| Santa Margarita to Omaha (Nebraska) | 4,890.10 mi (7,869.85 km) |
| Santa Margarita to On Top of the World Designated Place (Florida) | 4,740.30 mi (7,628.78 km) |
| Santa Margarita to Onalaska (Wisconsin) | 4,584.21 mi (7,377.57 km) |
| Santa Margarita to Oneida (New York) | 3,932.94 mi (6,329.45 km) |
| Santa Margarita to Oneonta (New York) | 3,924.44 mi (6,315.78 km) |
| Santa Margarita to Ontario (California) | 6,091.71 mi (9,803.65 km) |
| Santa Margarita to Ontario (Oregon) | 5,555.37 mi (8,940.50 km) |
| Santa Margarita to Opa-locka (Florida) | 4,764.45 mi (7,667.63 km) |
| Santa Margarita to Opelika (Alabama) | 4,752.35 mi (7,648.17 km) |
| Santa Margarita to Opelousas (Louisiana) | 5,158.41 mi (8,301.66 km) |
| Santa Margarita to Orange (California) | 6,112.08 mi (9,836.44 km) |
| Santa Margarita to Orange (Texas) | 5,254.63 mi (8,456.51 km) |
| Santa Margarita to Orange City (Florida) | 4,697.23 mi (7,559.46 km) |
| Santa Margarita to Orangeburg (South Carolina) | 4,502.88 mi (7,246.69 km) |
