| Santa Clarita to Superior (Colorado) | 826.08 mi (1,329.44 km) |
| Santa Clarita to Superior (Wisconsin) | 1,613.72 mi (2,597.03 km) |
| Santa Clarita to Surprise (Arizona) | 349.72 mi (562.81 km) |
| Santa Clarita to Susanville (California) | 430.69 mi (693.13 km) |
| Santa Clarita to Sussex (Wisconsin) | 1,726.92 mi (2,779.21 km) |
| Santa Clarita to Suwanee (Georgia) | 1,957.17 mi (3,149.77 km) |
| Santa Clarita to Swansea (Illinois) | 1,602.71 mi (2,579.31 km) |
| Santa Clarita to Sweetwater (Florida) | 2,340.81 mi (3,767.17 km) |
| Santa Clarita to Sweetwater (Texas) | 1,050.02 mi (1,689.84 km) |
| Santa Clarita to Sycamore (Illinois) | 1,691.29 mi (2,721.87 km) |
| Santa Clarita to Sylacauga (Alabama) | 1,845.08 mi (2,969.37 km) |
| Santa Clarita to Sylvania (Ohio) | 1,943.88 mi (3,128.36 km) |
| Santa Clarita to Syosset (New York) | 2,474.29 mi (3,981.99 km) |
| Santa Clarita to Syracuse (New York) | 2,332.82 mi (3,754.32 km) |
| Santa Clarita to Syracuse (Utah) | 578.88 mi (931.62 km) |
