| Santa Clarita to Southern Pines (North Carolina) | 2,203.98 mi (3,546.97 km) |
| Santa Clarita to Southfield (Michigan) | 1,970.56 mi (3,171.31 km) |
| Santa Clarita to Southgate (Michigan) | 1,971.94 mi (3,173.53 km) |
| Santa Clarita to Southlake (Texas) | 1,229.11 mi (1,978.06 km) |
| Santa Clarita to Spanaway (Washington) | 899.60 mi (1,447.76 km) |
| Santa Clarita to Spanish Fork (Utah) | 544.47 mi (876.23 km) |
| Santa Clarita to Spanish Lake (Missouri) | 1,591.25 mi (2,560.87 km) |
| Santa Clarita to Spanish Springs (Nevada) | 367.73 mi (591.80 km) |
| Santa Clarita to Sparks (Nevada) | 362.54 mi (583.46 km) |
| Santa Clarita to Spartanburg (South Carolina) | 2,066.48 mi (3,325.68 km) |
| Santa Clarita to Spearfish (South Dakota) | 1,044.84 mi (1,681.50 km) |
| Santa Clarita to Speedway (Indiana) | 1,805.15 mi (2,905.10 km) |
| Santa Clarita to Spencer (Iowa) | 1,388.11 mi (2,233.95 km) |
| Santa Clarita to Spokane (Washington) | 917.11 mi (1,475.95 km) |
| Santa Clarita to Spokane Valley (Washington) | 917.47 mi (1,476.53 km) |
