| Santa Clarita to Seymour (Tennessee) | 1,954.34 mi (3,145.21 km) |
| Santa Clarita to Shady Hills (Florida) | 2,148.63 mi (3,457.88 km) |
| Santa Clarita to Shafter (California) | 83.53 mi (134.42 km) |
| Santa Clarita to Shaker Heights (Ohio) | 2,054.65 mi (3,306.64 km) |
| Santa Clarita to Shakopee (Minnesota) | 1,503.35 mi (2,419.40 km) |
| Santa Clarita to Sharon (Pennsylvania) | 2,108.81 mi (3,393.80 km) |
| Santa Clarita to Sharonville (Ohio) | 1,902.94 mi (3,062.49 km) |
| Santa Clarita to Shasta Lake (California) | 481.91 mi (775.56 km) |
| Santa Clarita to Shawnee (Kansas) | 1,345.73 mi (2,165.75 km) |
| Santa Clarita to Shawnee (Oklahoma) | 1,219.67 mi (1,962.86 km) |
| Santa Clarita to Sheboygan (Wisconsin) | 1,758.82 mi (2,830.54 km) |
| Santa Clarita to Shelby (North Carolina) | 2,083.74 mi (3,353.45 km) |
| Santa Clarita to Shelbyville (Indiana) | 1,829.71 mi (2,944.63 km) |
| Santa Clarita to Shelbyville (Kentucky) | 1,860.48 mi (2,994.15 km) |
| Santa Clarita to Shelbyville (Tennessee) | 1,808.15 mi (2,909.93 km) |
