| Santa Clarita to Security-Widefield (Colorado) | 820.07 mi (1,319.78 km) |
| Santa Clarita to Sedalia (Missouri) | 1,428.11 mi (2,298.32 km) |
| Santa Clarita to Sedro-Woolley (Washington) | 992.48 mi (1,597.25 km) |
| Santa Clarita to Seguin (Texas) | 1,245.73 mi (2,004.81 km) |
| Santa Clarita to Selden (New York) | 2,497.70 mi (4,019.67 km) |
| Santa Clarita to Selma (Alabama) | 1,812.51 mi (2,916.95 km) |
| Santa Clarita to Selma (California) | 161.56 mi (260.01 km) |
| Santa Clarita to Selma (Texas) | 1,226.40 mi (1,973.70 km) |
| Santa Clarita to Seminole (Florida) | 2,148.86 mi (3,458.25 km) |
| Santa Clarita to Seven Hills (Ohio) | 2,048.06 mi (3,296.03 km) |
| Santa Clarita to Seven Oaks (South Carolina) | 2,121.59 mi (3,414.37 km) |
| Santa Clarita to Severn (Maryland) | 2,315.65 mi (3,726.67 km) |
| Santa Clarita to Severna Park (Maryland) | 2,322.73 mi (3,738.07 km) |
| Santa Clarita to Sevierville (Tennessee) | 1,965.32 mi (3,162.88 km) |
| Santa Clarita to Seymour (Indiana) | 1,823.58 mi (2,934.78 km) |
