| Santa Clarita to Scottsboro (Alabama) | 1,838.89 mi (2,959.41 km) |
| Santa Clarita to Scottsdale (Arizona) | 382.88 mi (616.19 km) |
| Santa Clarita to Scranton (Pennsylvania) | 2,359.42 mi (3,797.13 km) |
| Santa Clarita to Seabrook (Maryland) | 2,308.38 mi (3,714.98 km) |
| Santa Clarita to Seabrook (Texas) | 1,412.02 mi (2,272.43 km) |
| Santa Clarita to Seaford (New York) | 2,475.63 mi (3,984.14 km) |
| Santa Clarita to Seagoville (Texas) | 1,267.58 mi (2,039.97 km) |
| Santa Clarita to Seal Beach (California) | 51.88 mi (83.50 km) |
| Santa Clarita to Searcy (Arkansas) | 1,514.26 mi (2,436.96 km) |
| Santa Clarita to Seaside (California) | 241.09 mi (388.00 km) |
| Santa Clarita to SeaTac (Washington) | 921.39 mi (1,482.83 km) |
| Santa Clarita to Seattle (Washington) | 933.54 mi (1,502.38 km) |
| Santa Clarita to Sebastian (Florida) | 2,281.55 mi (3,671.80 km) |
| Santa Clarita to Sebring (Florida) | 2,233.93 mi (3,595.16 km) |
| Santa Clarita to Secaucus (New Jersey) | 2,445.07 mi (3,934.96 km) |
