| Santa Clarita to San Luis (Arizona) | 255.68 mi (411.47 km) |
| Santa Clarita to San Luis Obispo (California) | 136.46 mi (219.61 km) |
| Santa Clarita to San Marcos (California) | 116.69 mi (187.80 km) |
| Santa Clarita to San Marcos (Texas) | 1,240.68 mi (1,996.69 km) |
| Santa Clarita to San Marino (California) | 29.91 mi (48.13 km) |
| Santa Clarita to San Mateo (California) | 303.95 mi (489.16 km) |
| Santa Clarita to San Pablo (California) | 325.52 mi (523.87 km) |
| Santa Clarita to San Rafael (California) | 333.57 mi (536.83 km) |
| Santa Clarita to San Ramon (California) | 300.46 mi (483.54 km) |
| Santa Clarita to San Tan Valley (Arizona) | 407.11 mi (655.17 km) |
| Santa Clarita to Sand Springs (Oklahoma) | 1,264.46 mi (2,034.96 km) |
| Santa Clarita to Sandusky (Ohio) | 1,994.93 mi (3,210.53 km) |
| Santa Clarita to Sandy (Oregon) | 784.40 mi (1,262.37 km) |
| Santa Clarita to Sandy (Utah) | 559.54 mi (900.49 km) |
| Santa Clarita to Sandy Springs (Georgia) | 1,941.65 mi (3,124.79 km) |
