| Santa Clarita to Oskaloosa (Iowa) | 1,481.78 mi (2,384.70 km) |
| Santa Clarita to Oswego (Illinois) | 1,706.01 mi (2,745.55 km) |
| Santa Clarita to Oswego (New York) | 2,315.24 mi (3,726.01 km) |
| Santa Clarita to Otsego (Minnesota) | 1,508.66 mi (2,427.95 km) |
| Santa Clarita to Ottawa (Illinois) | 1,678.13 mi (2,700.69 km) |
| Santa Clarita to Ottawa (Kansas) | 1,318.37 mi (2,121.71 km) |
| Santa Clarita to Ottumwa (Iowa) | 1,489.94 mi (2,397.83 km) |
| Santa Clarita to Overland (Missouri) | 1,582.34 mi (2,546.53 km) |
| Santa Clarita to Overland Park (Kansas) | 1,351.24 mi (2,174.62 km) |
| Santa Clarita to Overlea (Maryland) | 2,323.73 mi (3,739.69 km) |
| Santa Clarita to Oviedo (Florida) | 2,220.08 mi (3,572.88 km) |
| Santa Clarita to Owasso (Oklahoma) | 1,280.83 mi (2,061.30 km) |
| Santa Clarita to Owatonna (Minnesota) | 1,499.64 mi (2,413.43 km) |
| Santa Clarita to Owensboro (Kentucky) | 1,758.89 mi (2,830.67 km) |
| Santa Clarita to Owings Mills (Maryland) | 2,308.89 mi (3,715.80 km) |
