| Santa Clarita to Orangeburg (South Carolina) | 2,145.04 mi (3,452.10 km) |
| Santa Clarita to Orangevale (California) | 331.52 mi (533.53 km) |
| Santa Clarita to Orchards (Washington) | 807.19 mi (1,299.05 km) |
| Santa Clarita to Orcutt (California) | 113.83 mi (183.19 km) |
| Santa Clarita to Oregon (Ohio) | 1,957.92 mi (3,150.96 km) |
| Santa Clarita to Oregon (Wisconsin) | 1,666.35 mi (2,681.73 km) |
| Santa Clarita to Oregon City (Oregon) | 785.13 mi (1,263.55 km) |
| Santa Clarita to Orem (Utah) | 551.39 mi (887.38 km) |
| Santa Clarita to Orinda (California) | 315.33 mi (507.48 km) |
| Santa Clarita to Orland Park (Illinois) | 1,729.74 mi (2,783.75 km) |
| Santa Clarita to Orlando (Florida) | 2,215.83 mi (3,566.03 km) |
| Santa Clarita to Ormond Beach (Florida) | 2,210.24 mi (3,557.03 km) |
| Santa Clarita to Oro Valley (Arizona) | 454.94 mi (732.15 km) |
| Santa Clarita to Oroville (California) | 389.79 mi (627.30 km) |
| Santa Clarita to Oshkosh (Wisconsin) | 1,722.27 mi (2,771.72 km) |
