| Santa Clarita to Olympia (Washington) | 901.76 mi (1,451.24 km) |
| Santa Clarita to Olympia Heights (Florida) | 2,344.46 mi (3,773.04 km) |
| Santa Clarita to Omaha (Nebraska) | 1,308.09 mi (2,105.17 km) |
| Santa Clarita to On Top of the World Designated Place (Florida) | 2,147.05 mi (3,455.34 km) |
| Santa Clarita to Onalaska (Wisconsin) | 1,592.21 mi (2,562.41 km) |
| Santa Clarita to Oneida (New York) | 2,357.14 mi (3,793.45 km) |
| Santa Clarita to Oneonta (New York) | 2,387.82 mi (3,842.82 km) |
| Santa Clarita to Ontario (California) | 57.16 mi (92.00 km) |
| Santa Clarita to Ontario (Oregon) | 668.81 mi (1,076.35 km) |
| Santa Clarita to Opa-locka (Florida) | 2,344.29 mi (3,772.77 km) |
| Santa Clarita to Opelika (Alabama) | 1,902.75 mi (3,062.19 km) |
| Santa Clarita to Opelousas (Louisiana) | 1,558.48 mi (2,508.14 km) |
| Santa Clarita to Orange (California) | 57.33 mi (92.27 km) |
| Santa Clarita to Orange (Texas) | 1,471.34 mi (2,367.89 km) |
| Santa Clarita to Orange City (Florida) | 2,207.88 mi (3,553.24 km) |
