| Santa Clarita to Indianapolis (Indiana) | 1,810.55 mi (2,913.79 km) |
| Santa Clarita to Indianola (Iowa) | 1,435.57 mi (2,310.33 km) |
| Santa Clarita to Indio (California) | 137.77 mi (221.72 km) |
| Santa Clarita to Inglewood (California) | 33.01 mi (53.12 km) |
| Santa Clarita to Inkster (Michigan) | 1,966.82 mi (3,165.29 km) |
| Santa Clarita to Inver Grove Heights (Minnesota) | 1,523.80 mi (2,452.32 km) |
| Santa Clarita to Inwood (New York) | 2,462.39 mi (3,962.84 km) |
| Santa Clarita to Iona (Florida) | 2,230.38 mi (3,589.45 km) |
| Santa Clarita to Ionia (Michigan) | 1,882.54 mi (3,029.65 km) |
| Santa Clarita to Iowa City (Iowa) | 1,542.79 mi (2,482.88 km) |
| Santa Clarita to Irmo (South Carolina) | 2,117.92 mi (3,408.47 km) |
| Santa Clarita to Irondale (Alabama) | 1,817.48 mi (2,924.95 km) |
| Santa Clarita to Ironton (Ohio) | 1,997.51 mi (3,214.69 km) |
| Santa Clarita to Irvine (California) | 65.78 mi (105.87 km) |
| Santa Clarita to Irving (Texas) | 1,240.61 mi (1,996.58 km) |
