| Santa Clarita to Enterprise (Nevada) | 214.78 mi (345.65 km) |
| Santa Clarita to Enumclaw (Washington) | 901.75 mi (1,451.23 km) |
| Santa Clarita to Ephrata (Pennsylvania) | 2,337.15 mi (3,761.28 km) |
| Santa Clarita to Erie (Colorado) | 834.77 mi (1,343.43 km) |
| Santa Clarita to Erie (Pennsylvania) | 2,131.87 mi (3,430.91 km) |
| Santa Clarita to Erlanger (Kentucky) | 1,893.60 mi (3,047.46 km) |
| Santa Clarita to Escanaba (Michigan) | 1,819.95 mi (2,928.93 km) |
| Santa Clarita to Escondido (California) | 120.59 mi (194.08 km) |
| Santa Clarita to Española (New Mexico) | 709.58 mi (1,141.95 km) |
| Santa Clarita to Essex (Maryland) | 2,327.98 mi (3,746.52 km) |
| Santa Clarita to Essex Junction (Vermont) | 2,484.53 mi (3,998.47 km) |
| Santa Clarita to Estelle (Louisiana) | 1,685.38 mi (2,712.36 km) |
| Santa Clarita to Estero (Florida) | 2,242.17 mi (3,608.42 km) |
| Santa Clarita to Euclid (Ohio) | 2,056.47 mi (3,309.56 km) |
| Santa Clarita to Eufaula (Alabama) | 1,927.80 mi (3,102.49 km) |
