| Santa Clarita to Elyria (Ohio) | 2,025.64 mi (3,259.95 km) |
| Santa Clarita to Emeryville (California) | 317.36 mi (510.74 km) |
| Santa Clarita to Emmaus (Pennsylvania) | 2,371.40 mi (3,816.40 km) |
| Santa Clarita to Emporia (Kansas) | 1,267.02 mi (2,039.07 km) |
| Santa Clarita to Encinitas (California) | 118.22 mi (190.26 km) |
| Santa Clarita to Endicott (New York) | 2,337.37 mi (3,761.63 km) |
| Santa Clarita to Endwell (New York) | 2,339.49 mi (3,765.05 km) |
| Santa Clarita to Englewood (Colorado) | 826.56 mi (1,330.23 km) |
| Santa Clarita to Englewood (Florida) | 2,195.86 mi (3,533.89 km) |
| Santa Clarita to Englewood (New Jersey) | 2,449.32 mi (3,941.79 km) |
| Santa Clarita to Englewood (Ohio) | 1,908.21 mi (3,070.97 km) |
| Santa Clarita to Enid (Oklahoma) | 1,167.35 mi (1,878.67 km) |
| Santa Clarita to Ennis (Texas) | 1,267.22 mi (2,039.40 km) |
| Santa Clarita to Ensley (Florida) | 1,832.46 mi (2,949.05 km) |
| Santa Clarita to Enterprise (Alabama) | 1,898.49 mi (3,055.33 km) |
