| Santa Clarita to Effingham (Illinois) | 1,680.99 mi (2,705.30 km) |
| Santa Clarita to Eggertsville (New York) | 2,198.20 mi (3,537.67 km) |
| Santa Clarita to Egypt Lake-Leto (Florida) | 2,160.35 mi (3,476.75 km) |
| Santa Clarita to El Cajon (California) | 142.39 mi (229.15 km) |
| Santa Clarita to El Campo (Texas) | 1,350.64 mi (2,173.65 km) |
| Santa Clarita to El Centro (California) | 203.12 mi (326.89 km) |
| Santa Clarita to El Cerrito (California) | 321.83 mi (517.94 km) |
| Santa Clarita to El Dorado (Arkansas) | 1,481.18 mi (2,383.73 km) |
| Santa Clarita to El Dorado (Kansas) | 1,227.28 mi (1,975.12 km) |
| Santa Clarita to El Dorado Hills (California) | 326.47 mi (525.40 km) |
| Santa Clarita to El Mirage (Arizona) | 357.90 mi (575.98 km) |
| Santa Clarita to El Monte (California) | 35.72 mi (57.49 km) |
| Santa Clarita to El Paso (Texas) | 719.88 mi (1,158.53 km) |
| Santa Clarita to El Paso de Robles (California) | 148.51 mi (239.00 km) |
| Santa Clarita to El Reno (Oklahoma) | 1,162.76 mi (1,871.27 km) |
