| Santa Clarita to Des Plaines (Illinois) | 1,731.39 mi (2,786.40 km) |
| Santa Clarita to Desert Hot Springs (California) | 116.13 mi (186.90 km) |
| Santa Clarita to DeSoto (Texas) | 1,250.22 mi (2,012.03 km) |
| Santa Clarita to Destin (Florida) | 1,880.86 mi (3,026.95 km) |
| Santa Clarita to Destrehan (Louisiana) | 1,667.74 mi (2,683.97 km) |
| Santa Clarita to Detroit (Michigan) | 1,978.10 mi (3,183.45 km) |
| Santa Clarita to Diamond Bar (California) | 48.44 mi (77.96 km) |
| Santa Clarita to Diamond Springs (California) | 322.66 mi (519.27 km) |
| Santa Clarita to Dickinson (North Dakota) | 1,187.44 mi (1,911.00 km) |
| Santa Clarita to Dickinson (Texas) | 1,412.86 mi (2,273.77 km) |
| Santa Clarita to Dickson (Tennessee) | 1,752.90 mi (2,821.03 km) |
| Santa Clarita to Difficult Run (Virginia) | 2,282.29 mi (3,673.00 km) |
| Santa Clarita to Dinuba (California) | 155.53 mi (250.31 km) |
| Santa Clarita to Discovery Bay (California) | 296.70 mi (477.50 km) |
| Santa Clarita to Dix Hills (New York) | 2,482.93 mi (3,995.90 km) |
