| San Mateo to Southern Pines (North Carolina) | 2,371.95 mi (3,817.28 km) |
| San Mateo to Southfield (Michigan) | 2,075.63 mi (3,340.41 km) |
| San Mateo to Southgate (Michigan) | 2,079.77 mi (3,347.07 km) |
| San Mateo to Southlake (Texas) | 1,450.10 mi (2,333.71 km) |
| San Mateo to Spanaway (Washington) | 659.57 mi (1,061.47 km) |
| San Mateo to Spanish Fork (Utah) | 600.51 mi (966.43 km) |
| San Mateo to Spanish Lake (Missouri) | 1,737.03 mi (2,795.48 km) |
| San Mateo to Spanish Springs (Nevada) | 203.71 mi (327.84 km) |
| San Mateo to Sparks (Nevada) | 197.91 mi (318.51 km) |
| San Mateo to Spartanburg (South Carolina) | 2,240.37 mi (3,605.52 km) |
| San Mateo to Spearfish (South Dakota) | 1,073.45 mi (1,727.56 km) |
| San Mateo to Speedway (Indiana) | 1,938.41 mi (3,119.56 km) |
| San Mateo to Spencer (Iowa) | 1,474.18 mi (2,372.46 km) |
| San Mateo to Spokane (Washington) | 741.21 mi (1,192.87 km) |
| San Mateo to Spokane Valley (Washington) | 744.33 mi (1,197.88 km) |
