| San Mateo to Scottsboro (Alabama) | 2,021.92 mi (3,253.96 km) |
| San Mateo to Scottsdale (Arizona) | 644.17 mi (1,036.69 km) |
| San Mateo to Scranton (Pennsylvania) | 2,471.86 mi (3,978.07 km) |
| San Mateo to Seabrook (Maryland) | 2,442.30 mi (3,930.51 km) |
| San Mateo to Seabrook (Texas) | 1,657.83 mi (2,668.02 km) |
| San Mateo to Seaford (New York) | 2,592.50 mi (4,172.23 km) |
| San Mateo to Seagoville (Texas) | 1,490.24 mi (2,398.30 km) |
| San Mateo to Seal Beach (California) | 354.24 mi (570.09 km) |
| San Mateo to Searcy (Arkansas) | 1,700.51 mi (2,736.71 km) |
| San Mateo to Seaside (California) | 69.74 mi (112.23 km) |
| San Mateo to SeaTac (Washington) | 683.49 mi (1,099.96 km) |
| San Mateo to Seattle (Washington) | 695.69 mi (1,119.61 km) |
| San Mateo to Sebastian (Florida) | 2,502.75 mi (4,027.79 km) |
| San Mateo to Sebring (Florida) | 2,459.16 mi (3,957.64 km) |
| San Mateo to Secaucus (New Jersey) | 2,561.51 mi (4,122.36 km) |
