| San Mateo to Sanford (Maine) | 2,695.76 mi (4,338.41 km) |
| San Mateo to Sanford (North Carolina) | 2,378.36 mi (3,827.60 km) |
| San Mateo to Sanger (California) | 162.79 mi (261.98 km) |
| San Mateo to Santa Ana (California) | 362.36 mi (583.17 km) |
| San Mateo to Santa Barbara (California) | 259.93 mi (418.31 km) |
| San Mateo to Santa Clara (California) | 22.89 mi (36.85 km) |
| San Mateo to Santa Clara (Oregon) | 455.50 mi (733.05 km) |
| San Mateo to Santa Clarita (California) | 303.95 mi (489.16 km) |
| San Mateo to Santa Cruz (California) | 42.45 mi (68.31 km) |
| San Mateo to Santa Fe (New Mexico) | 913.92 mi (1,470.81 km) |
| San Mateo to Santa Fe (Texas) | 1,659.52 mi (2,670.73 km) |
| San Mateo to Santa Fe Springs (California) | 345.36 mi (555.80 km) |
| San Mateo to Santa Maria (California) | 208.77 mi (335.98 km) |
| San Mateo to Santa Monica (California) | 324.82 mi (522.74 km) |
| San Mateo to Santa Paula (California) | 285.94 mi (460.17 km) |
