| Rutherglen to Sestu | 1,294.52 mi (2,083.32 km) |
| Rutherglen to Settimo Torinese | 904.72 mi (1,456.01 km) |
| Rutherglen to Seveso | 911.15 mi (1,466.35 km) |
| Rutherglen to Sezze | 1,258.33 mi (2,025.09 km) |
| Rutherglen to Siano | 1,344.64 mi (2,163.99 km) |
| Rutherglen to Siena | 1,104.80 mi (1,778.00 km) |
| Rutherglen to Signa | 1,071.60 mi (1,724.57 km) |
| Rutherglen to Silea | 1,002.77 mi (1,613.80 km) |
| Rutherglen to Silvi Paese | 1,228.03 mi (1,976.32 km) |
| Rutherglen to Sinalunga | 1,121.77 mi (1,805.31 km) |
| Rutherglen to Siniscola | 1,228.19 mi (1,976.57 km) |
| Rutherglen to Sinnai | 1,296.72 mi (2,086.87 km) |
| Rutherglen to Siracusa | 1,582.39 mi (2,546.61 km) |
| Rutherglen to Solaro | 911.30 mi (1,466.59 km) |
| Rutherglen to Soliera | 1,012.34 mi (1,629.20 km) |
