| Roseburg to Southern Pines (North Carolina) | 2,388.54 mi (3,843.99 km) |
| Roseburg to Southfield (Michigan) | 2,011.83 mi (3,237.72 km) |
| Roseburg to Southgate (Michigan) | 2,019.56 mi (3,250.18 km) |
| Roseburg to Southlake (Texas) | 1,582.56 mi (2,546.88 km) |
| Roseburg to Spanaway (Washington) | 271.51 mi (436.96 km) |
| Roseburg to Spanish Fork (Utah) | 640.93 mi (1,031.48 km) |
| Roseburg to Spanish Lake (Missouri) | 1,743.34 mi (2,805.63 km) |
| Roseburg to Spanish Springs (Nevada) | 311.54 mi (501.37 km) |
| Roseburg to Sparks (Nevada) | 314.72 mi (506.49 km) |
| Roseburg to Spartanburg (South Carolina) | 2,269.45 mi (3,652.32 km) |
| Roseburg to Spearfish (South Dakota) | 974.92 mi (1,568.99 km) |
| Roseburg to Speedway (Indiana) | 1,918.47 mi (3,087.48 km) |
| Roseburg to Spencer (Iowa) | 1,413.84 mi (2,275.36 km) |
| Roseburg to Spokane (Washington) | 420.00 mi (675.92 km) |
| Roseburg to Spokane Valley (Washington) | 426.39 mi (686.21 km) |
