| Roseburg to Scottsboro (Alabama) | 2,071.58 mi (3,333.89 km) |
| Roseburg to Scottsdale (Arizona) | 904.05 mi (1,454.93 km) |
| Roseburg to Scranton (Pennsylvania) | 2,406.40 mi (3,872.72 km) |
| Roseburg to Seabrook (Maryland) | 2,407.48 mi (3,874.46 km) |
| Roseburg to Seabrook (Texas) | 1,822.68 mi (2,933.33 km) |
| Roseburg to Seaford (New York) | 2,530.23 mi (4,072.01 km) |
| Roseburg to Seagoville (Texas) | 1,623.31 mi (2,612.46 km) |
| Roseburg to Seal Beach (California) | 713.46 mi (1,148.20 km) |
| Roseburg to Searcy (Arkansas) | 1,767.45 mi (2,844.44 km) |
| Roseburg to Seaside (California) | 463.21 mi (745.46 km) |
| Roseburg to SeaTac (Washington) | 296.11 mi (476.54 km) |
| Roseburg to Seattle (Washington) | 307.92 mi (495.55 km) |
| Roseburg to Sebastian (Florida) | 2,601.69 mi (4,187.01 km) |
| Roseburg to Sebring (Florida) | 2,566.01 mi (4,129.59 km) |
| Roseburg to Secaucus (New Jersey) | 2,499.37 mi (4,022.35 km) |
