| Roseburg to Oskaloosa (Iowa) | 1,567.33 mi (2,522.38 km) |
| Roseburg to Oswego (Illinois) | 1,775.13 mi (2,856.80 km) |
| Roseburg to Oswego (New York) | 2,322.61 mi (3,737.88 km) |
| Roseburg to Otsego (Minnesota) | 1,469.97 mi (2,365.69 km) |
| Roseburg to Ottawa (Illinois) | 1,756.86 mi (2,827.40 km) |
| Roseburg to Ottawa (Kansas) | 1,493.53 mi (2,403.61 km) |
| Roseburg to Ottumwa (Iowa) | 1,583.50 mi (2,548.39 km) |
| Roseburg to Overland (Missouri) | 1,737.49 mi (2,796.21 km) |
| Roseburg to Overland Park (Kansas) | 1,515.43 mi (2,438.85 km) |
| Roseburg to Overlea (Maryland) | 2,414.01 mi (3,884.98 km) |
| Roseburg to Oviedo (Florida) | 2,531.65 mi (4,074.30 km) |
| Roseburg to Owasso (Oklahoma) | 1,530.23 mi (2,462.66 km) |
| Roseburg to Owatonna (Minnesota) | 1,498.45 mi (2,411.53 km) |
| Roseburg to Owensboro (Kentucky) | 1,925.43 mi (3,098.68 km) |
| Roseburg to Owings Mills (Maryland) | 2,399.23 mi (3,861.18 km) |
