| Roseburg to Enterprise (Nevada) | 659.19 mi (1,060.87 km) |
| Roseburg to Enumclaw (Washington) | 282.77 mi (455.08 km) |
| Roseburg to Ephrata (Pennsylvania) | 2,410.09 mi (3,878.66 km) |
| Roseburg to Erie (Colorado) | 968.77 mi (1,559.09 km) |
| Roseburg to Erie (Pennsylvania) | 2,175.19 mi (3,500.64 km) |
| Roseburg to Erlanger (Kentucky) | 2,020.38 mi (3,251.49 km) |
| Roseburg to Escanaba (Michigan) | 1,780.55 mi (2,865.53 km) |
| Roseburg to Escondido (California) | 775.42 mi (1,247.92 km) |
| Roseburg to Española (New Mexico) | 1,043.56 mi (1,679.44 km) |
| Roseburg to Essex (Maryland) | 2,419.22 mi (3,893.35 km) |
| Roseburg to Essex Junction (Vermont) | 2,464.41 mi (3,966.09 km) |
| Roseburg to Estelle (Louisiana) | 2,046.02 mi (3,292.75 km) |
| Roseburg to Estero (Florida) | 2,592.67 mi (4,172.51 km) |
| Roseburg to Euclid (Ohio) | 2,114.83 mi (3,403.48 km) |
| Roseburg to Eufaula (Alabama) | 2,210.61 mi (3,557.64 km) |
