| Rome to Southern Pines (North Carolina) | 4,740.08 mi (7,628.42 km) |
| Rome to Southfield (Michigan) | 4,606.67 mi (7,413.71 km) |
| Rome to Southgate (Michigan) | 4,615.52 mi (7,427.96 km) |
| Rome to Southlake (Texas) | 5,608.86 mi (9,026.59 km) |
| Rome to Spanaway (Washington) | 5,696.71 mi (9,167.97 km) |
| Rome to Spanish Fork (Utah) | 5,778.76 mi (9,300.02 km) |
| Rome to Spanish Lake (Missouri) | 5,050.16 mi (8,127.45 km) |
| Rome to Spanish Springs (Nevada) | 6,053.90 mi (9,742.81 km) |
| Rome to Sparks (Nevada) | 6,060.06 mi (9,752.73 km) |
| Rome to Spartanburg (South Carolina) | 4,863.66 mi (7,827.31 km) |
| Rome to Spearfish (South Dakota) | 5,288.73 mi (8,511.39 km) |
| Rome to Speedway (Indiana) | 4,842.71 mi (7,793.59 km) |
| Rome to Spencer (Iowa) | 5,044.93 mi (8,119.03 km) |
| Rome to Spokane (Washington) | 5,534.25 mi (8,906.52 km) |
| Rome to Spokane Valley (Washington) | 5,529.14 mi (8,898.30 km) |
