| Rocky Mount to Southern Pines (North Carolina) | 104.67 mi (168.45 km) |
| Rocky Mount to Southfield (Michigan) | 535.91 mi (862.46 km) |
| Rocky Mount to Southgate (Michigan) | 518.95 mi (835.17 km) |
| Rocky Mount to Southlake (Texas) | 1,119.66 mi (1,801.92 km) |
| Rocky Mount to Spanaway (Washington) | 2,395.74 mi (3,855.57 km) |
| Rocky Mount to Spanish Fork (Utah) | 1,852.01 mi (2,980.53 km) |
| Rocky Mount to Spanish Lake (Missouri) | 707.69 mi (1,138.91 km) |
| Rocky Mount to Spanish Springs (Nevada) | 2,278.69 mi (3,667.20 km) |
| Rocky Mount to Sparks (Nevada) | 2,281.88 mi (3,672.33 km) |
| Rocky Mount to Spartanburg (South Carolina) | 242.47 mi (390.22 km) |
| Rocky Mount to Spearfish (South Dakota) | 1,484.88 mi (2,389.68 km) |
| Rocky Mount to Speedway (Indiana) | 530.60 mi (853.92 km) |
| Rocky Mount to Spencer (Iowa) | 1,045.98 mi (1,683.34 km) |
| Rocky Mount to Spokane (Washington) | 2,166.32 mi (3,486.36 km) |
| Rocky Mount to Spokane Valley (Washington) | 2,157.13 mi (3,471.56 km) |
