| Rock Island to Superior (Colorado) | 769.90 mi (1,239.03 km) |
| Rock Island to Superior (Wisconsin) | 368.53 mi (593.09 km) |
| Rock Island to Surprise (Arizona) | 1,308.05 mi (2,105.10 km) |
| Rock Island to Susanville (California) | 1,561.05 mi (2,512.27 km) |
| Rock Island to Sussex (Wisconsin) | 166.65 mi (268.19 km) |
| Rock Island to Suwanee (Georgia) | 623.56 mi (1,003.53 km) |
| Rock Island to Swansea (Illinois) | 204.15 mi (328.55 km) |
| Rock Island to Sweetwater (Florida) | 1,230.83 mi (1,980.83 km) |
| Rock Island to Sweetwater (Texas) | 824.07 mi (1,326.22 km) |
| Rock Island to Sycamore (Illinois) | 104.51 mi (168.20 km) |
| Rock Island to Sylacauga (Alabama) | 619.96 mi (997.73 km) |
| Rock Island to Sylvania (Ohio) | 355.49 mi (572.10 km) |
| Rock Island to Syosset (New York) | 888.45 mi (1,429.82 km) |
| Rock Island to Syracuse (New York) | 745.38 mi (1,199.58 km) |
| Rock Island to Syracuse (Utah) | 1,113.16 mi (1,791.46 km) |
