| Rock Island to Southern Pines (North Carolina) | 744.11 mi (1,197.53 km) |
| Rock Island to Southfield (Michigan) | 382.37 mi (615.37 km) |
| Rock Island to Southgate (Michigan) | 383.00 mi (616.38 km) |
| Rock Island to Southlake (Texas) | 689.97 mi (1,110.40 km) |
| Rock Island to Spanaway (Washington) | 1,610.13 mi (2,591.25 km) |
| Rock Island to Spanish Fork (Utah) | 1,102.82 mi (1,774.82 km) |
| Rock Island to Spanish Lake (Missouri) | 186.33 mi (299.87 km) |
| Rock Island to Spanish Springs (Nevada) | 1,524.66 mi (2,453.71 km) |
| Rock Island to Sparks (Nevada) | 1,528.49 mi (2,459.87 km) |
| Rock Island to Spartanburg (South Carolina) | 650.68 mi (1,047.17 km) |
| Rock Island to Spearfish (South Dakota) | 699.77 mi (1,126.17 km) |
| Rock Island to Speedway (Indiana) | 255.05 mi (410.46 km) |
| Rock Island to Spencer (Iowa) | 260.66 mi (419.49 km) |
| Rock Island to Spokane (Washington) | 1,381.15 mi (2,222.75 km) |
| Rock Island to Spokane Valley (Washington) | 1,371.97 mi (2,207.97 km) |
