| Rock Island to Scottsboro (Alabama) | 532.03 mi (856.23 km) |
| Rock Island to Scottsdale (Arizona) | 1,278.91 mi (2,058.20 km) |
| Rock Island to Scranton (Pennsylvania) | 771.77 mi (1,242.04 km) |
| Rock Island to Seabrook (Maryland) | 743.70 mi (1,196.87 km) |
| Rock Island to Seabrook (Texas) | 858.62 mi (1,381.81 km) |
| Rock Island to Seaford (New York) | 890.53 mi (1,433.17 km) |
| Rock Island to Seagoville (Texas) | 691.80 mi (1,113.34 km) |
| Rock Island to Seal Beach (California) | 1,588.06 mi (2,555.74 km) |
| Rock Island to Searcy (Arkansas) | 434.81 mi (699.76 km) |
| Rock Island to Seaside (California) | 1,699.66 mi (2,735.34 km) |
| Rock Island to SeaTac (Washington) | 1,605.41 mi (2,583.66 km) |
| Rock Island to Seattle (Washington) | 1,607.32 mi (2,586.74 km) |
| Rock Island to Sebastian (Florida) | 1,104.58 mi (1,777.65 km) |
| Rock Island to Sebring (Florida) | 1,096.23 mi (1,764.21 km) |
| Rock Island to Secaucus (New Jersey) | 859.64 mi (1,383.46 km) |
