| Rock Island to Santa Rosa (California) | 1,704.22 mi (2,742.67 km) |
| Rock Island to Santaquin (Utah) | 1,112.77 mi (1,790.82 km) |
| Rock Island to Santee (California) | 1,563.03 mi (2,515.45 km) |
| Rock Island to Sapulpa (Oklahoma) | 480.16 mi (772.75 km) |
| Rock Island to Saraland (Alabama) | 746.76 mi (1,201.80 km) |
| Rock Island to Sarasota (Florida) | 1,077.34 mi (1,733.81 km) |
| Rock Island to Sarasota Springs (Florida) | 1,080.90 mi (1,739.53 km) |
| Rock Island to Saratoga (California) | 1,694.82 mi (2,727.55 km) |
| Rock Island to Saratoga Springs (New York) | 864.81 mi (1,391.78 km) |
| Rock Island to Saratoga Springs (Utah) | 1,113.84 mi (1,792.55 km) |
| Rock Island to Sartell (Minnesota) | 339.57 mi (546.49 km) |
| Rock Island to Satellite Beach (Florida) | 1,077.07 mi (1,733.37 km) |
| Rock Island to Sauk Rapids (Minnesota) | 336.60 mi (541.70 km) |
| Rock Island to Sault Ste. Marie (Michigan) | 463.67 mi (746.20 km) |
| Rock Island to Savage (Minnesota) | 266.74 mi (429.28 km) |
