| Rock Island to Enterprise (Nevada) | 1,375.42 mi (2,213.53 km) |
| Rock Island to Enumclaw (Washington) | 1,590.09 mi (2,559.00 km) |
| Rock Island to Ephrata (Pennsylvania) | 757.31 mi (1,218.77 km) |
| Rock Island to Erie (Colorado) | 762.17 mi (1,226.60 km) |
| Rock Island to Erie (Pennsylvania) | 542.86 mi (873.65 km) |
| Rock Island to Erlanger (Kentucky) | 358.88 mi (577.57 km) |
| Rock Island to Escanaba (Michigan) | 343.27 mi (552.44 km) |
| Rock Island to Escondido (California) | 1,557.86 mi (2,507.14 km) |
| Rock Island to Española (New Mexico) | 914.30 mi (1,471.43 km) |
| Rock Island to Essex (Maryland) | 758.05 mi (1,219.97 km) |
| Rock Island to Essex Junction (Vermont) | 905.41 mi (1,457.12 km) |
| Rock Island to Estelle (Louisiana) | 803.67 mi (1,293.39 km) |
| Rock Island to Estero (Florida) | 1,153.37 mi (1,856.17 km) |
| Rock Island to Euclid (Ohio) | 468.68 mi (754.26 km) |
| Rock Island to Eufaula (Alabama) | 725.45 mi (1,167.49 km) |
