| Rock Hill to Scottsboro (Alabama) | 285.83 mi (460.01 km) |
| Rock Hill to Scottsdale (Arizona) | 1,755.21 mi (2,824.74 km) |
| Rock Hill to Scranton (Pennsylvania) | 532.78 mi (857.43 km) |
| Rock Hill to Seabrook (Maryland) | 361.80 mi (582.26 km) |
| Rock Hill to Seabrook (Texas) | 896.95 mi (1,443.51 km) |
| Rock Hill to Seaford (New York) | 570.19 mi (917.63 km) |
| Rock Hill to Seagoville (Texas) | 904.15 mi (1,455.09 km) |
| Rock Hill to Seal Beach (California) | 2,102.84 mi (3,384.20 km) |
| Rock Hill to Searcy (Arkansas) | 605.60 mi (974.62 km) |
| Rock Hill to Seaside (California) | 2,272.39 mi (3,657.07 km) |
| Rock Hill to SeaTac (Washington) | 2,280.95 mi (3,670.84 km) |
| Rock Hill to Seattle (Washington) | 2,283.66 mi (3,675.20 km) |
| Rock Hill to Sebastian (Florida) | 495.69 mi (797.74 km) |
| Rock Hill to Sebring (Florida) | 516.37 mi (831.01 km) |
| Rock Hill to Secaucus (New Jersey) | 553.57 mi (890.88 km) |
