| Roanoke Rapids to University Place (Washington) | 2,391.29 mi (3,848.42 km) |
| Roanoke Rapids to Upland (California) | 2,246.34 mi (3,615.13 km) |
| Roanoke Rapids to Upper Arlington (Ohio) | 384.33 mi (618.53 km) |
| Roanoke Rapids to Upper Grand Lagoon (Florida) | 636.99 mi (1,025.14 km) |
| Roanoke Rapids to Upper Montclair (New Jersey) | 356.26 mi (573.34 km) |
| Roanoke Rapids to Urbana (Illinois) | 625.14 mi (1,006.07 km) |
| Roanoke Rapids to Urbana (Maryland) | 199.84 mi (321.61 km) |
| Roanoke Rapids to Urbana (Ohio) | 416.62 mi (670.48 km) |
| Roanoke Rapids to Urbandale (Iowa) | 935.27 mi (1,505.18 km) |
| Roanoke Rapids to Utica (New York) | 477.15 mi (767.90 km) |
| Roanoke Rapids to Uvalde (Texas) | 1,374.47 mi (2,211.99 km) |
| Roanoke Rapids to Vacaville (California) | 2,412.65 mi (3,882.78 km) |
| Roanoke Rapids to Vadnais Heights (Minnesota) | 1,000.16 mi (1,609.60 km) |
| Roanoke Rapids to Vail (Arizona) | 1,902.73 mi (3,062.15 km) |
| Roanoke Rapids to Valdosta (Georgia) | 504.06 mi (811.20 km) |
