| Roanoke Rapids to Superior (Colorado) | 1,507.11 mi (2,425.45 km) |
| Roanoke Rapids to Superior (Wisconsin) | 1,025.57 mi (1,650.50 km) |
| Roanoke Rapids to Surprise (Arizona) | 1,966.82 mi (3,165.28 km) |
| Roanoke Rapids to Susanville (California) | 2,318.59 mi (3,731.42 km) |
| Roanoke Rapids to Sussex (Wisconsin) | 726.14 mi (1,168.61 km) |
| Roanoke Rapids to Suwanee (Georgia) | 398.10 mi (640.69 km) |
| Roanoke Rapids to Swansea (Illinois) | 691.16 mi (1,112.31 km) |
| Roanoke Rapids to Sweetwater (Florida) | 754.34 mi (1,213.99 km) |
| Roanoke Rapids to Sweetwater (Texas) | 1,322.14 mi (2,127.77 km) |
| Roanoke Rapids to Sycamore (Illinois) | 703.28 mi (1,131.82 km) |
| Roanoke Rapids to Sylacauga (Alabama) | 537.86 mi (865.61 km) |
| Roanoke Rapids to Sylvania (Ohio) | 487.56 mi (784.66 km) |
| Roanoke Rapids to Syosset (New York) | 375.78 mi (604.76 km) |
| Roanoke Rapids to Syracuse (New York) | 462.65 mi (744.56 km) |
| Roanoke Rapids to Syracuse (Utah) | 1,869.40 mi (3,008.51 km) |
