| Roanoke Rapids to Storm Lake (Iowa) | 1,025.70 mi (1,650.70 km) |
| Roanoke Rapids to Storrs (Connecticut) | 469.90 mi (756.22 km) |
| Roanoke Rapids to Stoughton (Wisconsin) | 759.81 mi (1,222.79 km) |
| Roanoke Rapids to Stow (Ohio) | 385.13 mi (619.80 km) |
| Roanoke Rapids to Streamwood (Illinois) | 681.78 mi (1,097.22 km) |
| Roanoke Rapids to Streator (Illinois) | 682.71 mi (1,098.72 km) |
| Roanoke Rapids to Streetsboro (Ohio) | 386.31 mi (621.70 km) |
| Roanoke Rapids to Strongsville (Ohio) | 404.49 mi (650.97 km) |
| Roanoke Rapids to Stuart (Florida) | 656.90 mi (1,057.17 km) |
| Roanoke Rapids to Stuarts Draft (Virginia) | 132.80 mi (213.73 km) |
| Roanoke Rapids to Sturgis (Michigan) | 556.59 mi (895.75 km) |
| Roanoke Rapids to Suamico (Wisconsin) | 785.85 mi (1,264.70 km) |
| Roanoke Rapids to Sudley (Virginia) | 162.07 mi (260.83 km) |
| Roanoke Rapids to Suffern (New York) | 373.72 mi (601.44 km) |
| Roanoke Rapids to Suffolk (Virginia) | 58.61 mi (94.32 km) |
