| Roanoke Rapids to Stephenville (Texas) | 1,207.02 mi (1,942.51 km) |
| Roanoke Rapids to Sterling (Colorado) | 1,405.14 mi (2,261.35 km) |
| Roanoke Rapids to Sterling (Illinois) | 743.18 mi (1,196.03 km) |
| Roanoke Rapids to Sterling (Virginia) | 177.38 mi (285.47 km) |
| Roanoke Rapids to Sterling Heights (Michigan) | 511.61 mi (823.36 km) |
| Roanoke Rapids to Steubenville (Ohio) | 315.85 mi (508.32 km) |
| Roanoke Rapids to Stevens Point (Wisconsin) | 836.72 mi (1,346.58 km) |
| Roanoke Rapids to Stevenson Ranch (California) | 2,292.29 mi (3,689.08 km) |
| Roanoke Rapids to Stillwater (Minnesota) | 990.02 mi (1,593.29 km) |
| Roanoke Rapids to Stillwater (Oklahoma) | 1,080.22 mi (1,738.45 km) |
| Roanoke Rapids to Stockbridge (Georgia) | 423.48 mi (681.53 km) |
| Roanoke Rapids to Stockton (California) | 2,382.73 mi (3,834.63 km) |
| Roanoke Rapids to Stone Ridge (Virginia) | 171.72 mi (276.35 km) |
| Roanoke Rapids to Stonecrest (Georgia) | 413.42 mi (665.33 km) |
| Roanoke Rapids to Stony Brook (New York) | 392.91 mi (632.32 km) |
