| Roanoke Rapids to Southern Pines (North Carolina) | 130.98 mi (210.78 km) |
| Roanoke Rapids to Southfield (Michigan) | 512.82 mi (825.30 km) |
| Roanoke Rapids to Southgate (Michigan) | 496.30 mi (798.72 km) |
| Roanoke Rapids to Southlake (Texas) | 1,131.60 mi (1,821.14 km) |
| Roanoke Rapids to Spanaway (Washington) | 2,385.32 mi (3,838.81 km) |
| Roanoke Rapids to Spanish Fork (Utah) | 1,849.60 mi (2,976.65 km) |
| Roanoke Rapids to Spanish Lake (Missouri) | 705.51 mi (1,135.41 km) |
| Roanoke Rapids to Spanish Springs (Nevada) | 2,276.17 mi (3,663.14 km) |
| Roanoke Rapids to Sparks (Nevada) | 2,279.44 mi (3,668.40 km) |
| Roanoke Rapids to Spartanburg (South Carolina) | 261.37 mi (420.63 km) |
| Roanoke Rapids to Spearfish (South Dakota) | 1,475.44 mi (2,374.48 km) |
| Roanoke Rapids to Speedway (Indiana) | 521.23 mi (838.84 km) |
| Roanoke Rapids to Spencer (Iowa) | 1,035.42 mi (1,666.35 km) |
| Roanoke Rapids to Spokane (Washington) | 2,155.06 mi (3,468.23 km) |
| Roanoke Rapids to Spokane Valley (Washington) | 2,145.85 mi (3,453.41 km) |
