| Roanoke Rapids to Silver Firs (Washington) | 2,374.46 mi (3,821.33 km) |
| Roanoke Rapids to Silver Spring (Maryland) | 180.02 mi (289.71 km) |
| Roanoke Rapids to Silver Springs Shores (Florida) | 566.39 mi (911.51 km) |
| Roanoke Rapids to Silverdale (Washington) | 2,398.64 mi (3,860.23 km) |
| Roanoke Rapids to Silverton (Oregon) | 2,403.08 mi (3,867.38 km) |
| Roanoke Rapids to Simi Valley (California) | 2,303.41 mi (3,706.99 km) |
| Roanoke Rapids to Simpsonville (South Carolina) | 284.74 mi (458.24 km) |
| Roanoke Rapids to Sioux City (Iowa) | 1,080.52 mi (1,738.92 km) |
| Roanoke Rapids to Sioux Falls (South Dakota) | 1,119.20 mi (1,801.17 km) |
| Roanoke Rapids to Skokie (Illinois) | 663.19 mi (1,067.29 km) |
| Roanoke Rapids to Sleepy Hollow (New York) | 380.10 mi (611.71 km) |
| Roanoke Rapids to Slidell (Louisiana) | 818.26 mi (1,316.85 km) |
| Roanoke Rapids to Smithfield (North Carolina) | 75.36 mi (121.29 km) |
| Roanoke Rapids to Smithfield (Utah) | 1,856.21 mi (2,987.29 km) |
| Roanoke Rapids to Smithville (Missouri) | 943.24 mi (1,518.00 km) |
