| Roanoke Rapids to Seymour (Tennessee) | 343.45 mi (552.74 km) |
| Roanoke Rapids to Shady Hills (Florida) | 624.46 mi (1,004.97 km) |
| Roanoke Rapids to Shafter (California) | 2,306.54 mi (3,712.01 km) |
| Roanoke Rapids to Shaker Heights (Ohio) | 405.67 mi (652.87 km) |
| Roanoke Rapids to Shakopee (Minnesota) | 1,007.34 mi (1,621.15 km) |
| Roanoke Rapids to Sharon (Pennsylvania) | 364.66 mi (586.86 km) |
| Roanoke Rapids to Sharonville (Ohio) | 417.36 mi (671.67 km) |
| Roanoke Rapids to Shasta Lake (California) | 2,408.05 mi (3,875.38 km) |
| Roanoke Rapids to Shawnee (Kansas) | 952.81 mi (1,533.39 km) |
| Roanoke Rapids to Shawnee (Oklahoma) | 1,081.90 mi (1,741.15 km) |
| Roanoke Rapids to Sheboygan (Wisconsin) | 732.51 mi (1,178.86 km) |
| Roanoke Rapids to Shelby (North Carolina) | 232.26 mi (373.78 km) |
| Roanoke Rapids to Shelbyville (Indiana) | 491.25 mi (790.59 km) |
| Roanoke Rapids to Shelbyville (Kentucky) | 433.75 mi (698.05 km) |
| Roanoke Rapids to Shelbyville (Tennessee) | 496.37 mi (798.83 km) |
