| Roanoke Rapids to Security-Widefield (Colorado) | 1,484.74 mi (2,389.46 km) |
| Roanoke Rapids to Sedalia (Missouri) | 866.49 mi (1,394.48 km) |
| Roanoke Rapids to Sedro-Woolley (Washington) | 2,380.73 mi (3,831.42 km) |
| Roanoke Rapids to Seguin (Texas) | 1,265.71 mi (2,036.96 km) |
| Roanoke Rapids to Selden (New York) | 393.81 mi (633.77 km) |
| Roanoke Rapids to Selma (Alabama) | 602.51 mi (969.65 km) |
| Roanoke Rapids to Selma (California) | 2,311.52 mi (3,720.02 km) |
| Roanoke Rapids to Selma (Texas) | 1,284.26 mi (2,066.82 km) |
| Roanoke Rapids to Seminole (Florida) | 665.64 mi (1,071.24 km) |
| Roanoke Rapids to Seven Hills (Ohio) | 403.72 mi (649.73 km) |
| Roanoke Rapids to Seven Oaks (South Carolina) | 257.50 mi (414.41 km) |
| Roanoke Rapids to Severn (Maryland) | 193.03 mi (310.65 km) |
| Roanoke Rapids to Severna Park (Maryland) | 191.83 mi (308.71 km) |
| Roanoke Rapids to Sevierville (Tennessee) | 332.34 mi (534.85 km) |
| Roanoke Rapids to Seymour (Indiana) | 482.41 mi (776.36 km) |
