| Roanoke Rapids to Scottsboro (Alabama) | 488.18 mi (785.66 km) |
| Roanoke Rapids to Scottsdale (Arizona) | 1,934.23 mi (3,112.84 km) |
| Roanoke Rapids to Scranton (Pennsylvania) | 358.83 mi (577.48 km) |
| Roanoke Rapids to Seabrook (Maryland) | 180.51 mi (290.50 km) |
| Roanoke Rapids to Seabrook (Texas) | 1,110.69 mi (1,787.49 km) |
| Roanoke Rapids to Seaford (New York) | 368.09 mi (592.38 km) |
| Roanoke Rapids to Seagoville (Texas) | 1,104.83 mi (1,778.05 km) |
| Roanoke Rapids to Seal Beach (California) | 2,275.94 mi (3,662.78 km) |
| Roanoke Rapids to Searcy (Arkansas) | 792.59 mi (1,275.55 km) |
| Roanoke Rapids to Seaside (California) | 2,429.95 mi (3,910.62 km) |
| Roanoke Rapids to SeaTac (Washington) | 2,380.19 mi (3,830.55 km) |
| Roanoke Rapids to Seattle (Washington) | 2,381.85 mi (3,833.21 km) |
| Roanoke Rapids to Sebastian (Florida) | 621.00 mi (999.40 km) |
| Roanoke Rapids to Sebring (Florida) | 658.37 mi (1,059.55 km) |
| Roanoke Rapids to Secaucus (New Jersey) | 356.52 mi (573.77 km) |
