| Roanoke Rapids to Sanford (Maine) | 604.37 mi (972.64 km) |
| Roanoke Rapids to Sanford (North Carolina) | 108.07 mi (173.92 km) |
| Roanoke Rapids to Sanger (California) | 2,306.53 mi (3,712.00 km) |
| Roanoke Rapids to Santa Ana (California) | 2,265.84 mi (3,646.52 km) |
| Roanoke Rapids to Santa Barbara (California) | 2,353.68 mi (3,787.87 km) |
| Roanoke Rapids to Santa Clara (California) | 2,426.54 mi (3,905.14 km) |
| Roanoke Rapids to Santa Clara (Oregon) | 2,423.28 mi (3,899.90 km) |
| Roanoke Rapids to Santa Clarita (California) | 2,286.72 mi (3,680.12 km) |
| Roanoke Rapids to Santa Cruz (California) | 2,435.94 mi (3,920.26 km) |
| Roanoke Rapids to Santa Fe (New Mexico) | 1,577.89 mi (2,539.37 km) |
| Roanoke Rapids to Santa Fe (Texas) | 1,121.14 mi (1,804.30 km) |
| Roanoke Rapids to Santa Fe Springs (California) | 2,271.99 mi (3,656.42 km) |
| Roanoke Rapids to Santa Maria (California) | 2,383.92 mi (3,836.55 km) |
| Roanoke Rapids to Santa Monica (California) | 2,293.29 mi (3,690.69 km) |
| Roanoke Rapids to Santa Paula (California) | 2,319.15 mi (3,732.30 km) |
