| Roanoke Rapids to Oskaloosa (Iowa) | 871.74 mi (1,402.93 km) |
| Roanoke Rapids to Oswego (Illinois) | 677.27 mi (1,089.97 km) |
| Roanoke Rapids to Oswego (New York) | 487.89 mi (785.18 km) |
| Roanoke Rapids to Otsego (Minnesota) | 1,030.37 mi (1,658.22 km) |
| Roanoke Rapids to Ottawa (Illinois) | 689.35 mi (1,109.40 km) |
| Roanoke Rapids to Ottawa (Kansas) | 975.11 mi (1,569.30 km) |
| Roanoke Rapids to Ottumwa (Iowa) | 855.12 mi (1,376.18 km) |
| Roanoke Rapids to Overland (Missouri) | 713.10 mi (1,147.62 km) |
| Roanoke Rapids to Overland Park (Kansas) | 945.55 mi (1,521.72 km) |
| Roanoke Rapids to Overlea (Maryland) | 210.90 mi (339.41 km) |
| Roanoke Rapids to Oviedo (Florida) | 576.02 mi (927.02 km) |
| Roanoke Rapids to Owasso (Oklahoma) | 1,010.15 mi (1,625.68 km) |
| Roanoke Rapids to Owatonna (Minnesota) | 974.18 mi (1,567.80 km) |
| Roanoke Rapids to Owensboro (Kentucky) | 529.34 mi (851.89 km) |
| Roanoke Rapids to Owings Mills (Maryland) | 210.21 mi (338.30 km) |
