| Roanoke Rapids to Orangeburg (South Carolina) | 273.48 mi (440.12 km) |
| Roanoke Rapids to Orangevale (California) | 2,368.81 mi (3,812.24 km) |
| Roanoke Rapids to Orchards (Washington) | 2,389.85 mi (3,846.10 km) |
| Roanoke Rapids to Orcutt (California) | 2,383.95 mi (3,836.59 km) |
| Roanoke Rapids to Oregon (Ohio) | 474.88 mi (764.24 km) |
| Roanoke Rapids to Oregon (Wisconsin) | 767.02 mi (1,234.40 km) |
| Roanoke Rapids to Oregon City (Oregon) | 2,393.26 mi (3,851.58 km) |
| Roanoke Rapids to Orem (Utah) | 1,852.03 mi (2,980.56 km) |
| Roanoke Rapids to Orinda (California) | 2,430.41 mi (3,911.37 km) |
| Roanoke Rapids to Orland Park (Illinois) | 653.30 mi (1,051.39 km) |
| Roanoke Rapids to Orlando (Florida) | 590.88 mi (950.93 km) |
| Roanoke Rapids to Ormond Beach (Florida) | 532.77 mi (857.41 km) |
| Roanoke Rapids to Oro Valley (Arizona) | 1,909.91 mi (3,073.70 km) |
| Roanoke Rapids to Oroville (California) | 2,377.52 mi (3,826.24 km) |
| Roanoke Rapids to Oshkosh (Wisconsin) | 776.86 mi (1,250.23 km) |
