| Roanoke Rapids to Olympia (Washington) | 2,407.48 mi (3,874.46 km) |
| Roanoke Rapids to Olympia Heights (Florida) | 757.57 mi (1,219.18 km) |
| Roanoke Rapids to Omaha (Nebraska) | 1,042.28 mi (1,677.38 km) |
| Roanoke Rapids to On Top of the World Designated Place (Florida) | 574.02 mi (923.80 km) |
| Roanoke Rapids to Onalaska (Wisconsin) | 879.60 mi (1,415.57 km) |
| Roanoke Rapids to Oneida (New York) | 470.16 mi (756.65 km) |
| Roanoke Rapids to Oneonta (New York) | 437.44 mi (704.00 km) |
| Roanoke Rapids to Ontario (California) | 2,244.85 mi (3,612.73 km) |
| Roanoke Rapids to Ontario (Oregon) | 2,117.88 mi (3,408.39 km) |
| Roanoke Rapids to Opa-locka (Florida) | 744.64 mi (1,198.38 km) |
| Roanoke Rapids to Opelika (Alabama) | 511.35 mi (822.94 km) |
| Roanoke Rapids to Opelousas (Louisiana) | 925.46 mi (1,489.38 km) |
| Roanoke Rapids to Orange (California) | 2,261.22 mi (3,639.09 km) |
| Roanoke Rapids to Orange (Texas) | 1,026.21 mi (1,651.53 km) |
| Roanoke Rapids to Orange City (Florida) | 560.27 mi (901.67 km) |
