| Roanoke Rapids to Enterprise (Nevada) | 2,081.24 mi (3,349.44 km) |
| Roanoke Rapids to Enumclaw (Washington) | 2,365.16 mi (3,806.36 km) |
| Roanoke Rapids to Ephrata (Pennsylvania) | 270.10 mi (434.68 km) |
| Roanoke Rapids to Erie (Colorado) | 1,500.88 mi (2,415.44 km) |
| Roanoke Rapids to Erie (Pennsylvania) | 412.70 mi (664.18 km) |
| Roanoke Rapids to Erlanger (Kentucky) | 418.35 mi (673.27 km) |
| Roanoke Rapids to Escanaba (Michigan) | 807.95 mi (1,300.27 km) |
| Roanoke Rapids to Escondido (California) | 2,233.15 mi (3,593.91 km) |
| Roanoke Rapids to Española (New Mexico) | 1,578.58 mi (2,540.47 km) |
| Roanoke Rapids to Essex (Maryland) | 208.02 mi (334.78 km) |
| Roanoke Rapids to Essex Junction (Vermont) | 604.56 mi (972.94 km) |
| Roanoke Rapids to Estelle (Louisiana) | 851.51 mi (1,370.38 km) |
| Roanoke Rapids to Estero (Florida) | 733.81 mi (1,180.96 km) |
| Roanoke Rapids to Euclid (Ohio) | 411.63 mi (662.45 km) |
| Roanoke Rapids to Eufaula (Alabama) | 530.78 mi (854.21 km) |
