| Roanoke Rapids to Elyria (Ohio) | 416.38 mi (670.09 km) |
| Roanoke Rapids to Emeryville (California) | 2,437.11 mi (3,922.15 km) |
| Roanoke Rapids to Emmaus (Pennsylvania) | 305.57 mi (491.77 km) |
| Roanoke Rapids to Emporia (Kansas) | 1,024.72 mi (1,649.13 km) |
| Roanoke Rapids to Encinitas (California) | 2,245.34 mi (3,613.53 km) |
| Roanoke Rapids to Endicott (New York) | 399.65 mi (643.17 km) |
| Roanoke Rapids to Endwell (New York) | 401.50 mi (646.15 km) |
| Roanoke Rapids to Englewood (Colorado) | 1,498.34 mi (2,411.35 km) |
| Roanoke Rapids to Englewood (Florida) | 710.27 mi (1,143.08 km) |
| Roanoke Rapids to Englewood (New Jersey) | 365.56 mi (588.32 km) |
| Roanoke Rapids to Englewood (Ohio) | 431.85 mi (695.00 km) |
| Roanoke Rapids to Enid (Oklahoma) | 1,122.10 mi (1,805.85 km) |
| Roanoke Rapids to Ennis (Texas) | 1,117.28 mi (1,798.08 km) |
| Roanoke Rapids to Ensley (Florida) | 688.48 mi (1,108.00 km) |
| Roanoke Rapids to Enterprise (Alabama) | 587.91 mi (946.14 km) |
