| Roanoke to Yonkers (New York) | 413.16 mi (664.92 km) |
| Roanoke to Yorba Linda (California) | 2,123.52 mi (3,417.47 km) |
| Roanoke to York (Pennsylvania) | 254.51 mi (409.59 km) |
| Roanoke to Yorktown (Indiana) | 360.29 mi (579.83 km) |
| Roanoke to Yorkville (Illinois) | 544.27 mi (875.93 km) |
| Roanoke to Youngstown (Ohio) | 266.55 mi (428.97 km) |
| Roanoke to Youngsville (Louisiana) | 850.45 mi (1,368.67 km) |
| Roanoke to Ypsilanti (Michigan) | 394.30 mi (634.56 km) |
| Roanoke to Yuba City (California) | 2,246.61 mi (3,615.57 km) |
| Roanoke to Yucaipa (California) | 2,080.68 mi (3,348.53 km) |
| Roanoke to Yucca Valley (California) | 2,044.86 mi (3,290.88 km) |
| Roanoke to Yukon (Oklahoma) | 996.16 mi (1,603.17 km) |
| Roanoke to Yulee (Florida) | 468.18 mi (753.46 km) |
| Roanoke to Yuma (Arizona) | 1,974.54 mi (3,177.72 km) |
| Roanoke to Zachary (Louisiana) | 787.15 mi (1,266.79 km) |
