| Roanoke to Worthington (Ohio) | 255.22 mi (410.74 km) |
| Roanoke to Wright (Florida) | 607.91 mi (978.33 km) |
| Roanoke to Wyandanch (New York) | 427.43 mi (687.88 km) |
| Roanoke to Wyandotte (Michigan) | 380.74 mi (612.74 km) |
| Roanoke to Wylie (Texas) | 978.65 mi (1,574.99 km) |
| Roanoke to Wyndham (Virginia) | 131.75 mi (212.03 km) |
| Roanoke to Wyoming (Michigan) | 492.39 mi (792.43 km) |
| Roanoke to Wyomissing (Pennsylvania) | 300.94 mi (484.32 km) |
| Roanoke to Xenia (Ohio) | 272.00 mi (437.75 km) |
| Roanoke to Yakima (Washington) | 2,156.66 mi (3,470.80 km) |
| Roanoke to Yankton (South Dakota) | 997.45 mi (1,605.25 km) |
| Roanoke to Yauco (Puerto Rico) | 1,548.76 mi (2,492.49 km) |
| Roanoke to Yazoo City (Mississippi) | 664.49 mi (1,069.39 km) |
| Roanoke to Yeadon (Pennsylvania) | 313.25 mi (504.13 km) |
| Roanoke to Yelm (Washington) | 2,255.71 mi (3,630.22 km) |
