| Roanoke to University Place (Washington) | 2,252.52 mi (3,625.07 km) |
| Roanoke to Upland (California) | 2,112.78 mi (3,400.20 km) |
| Roanoke to Upper Arlington (Ohio) | 253.48 mi (407.93 km) |
| Roanoke to Upper Grand Lagoon (Florida) | 592.76 mi (953.95 km) |
| Roanoke to Upper Montclair (New Jersey) | 394.91 mi (635.54 km) |
| Roanoke to Urbana (Illinois) | 485.24 mi (780.91 km) |
| Roanoke to Urbana (Maryland) | 200.37 mi (322.47 km) |
| Roanoke to Urbana (Ohio) | 283.03 mi (455.50 km) |
| Roanoke to Urbandale (Iowa) | 795.41 mi (1,280.08 km) |
| Roanoke to Utica (New York) | 473.05 mi (761.30 km) |
| Roanoke to Uvalde (Texas) | 1,270.09 mi (2,044.01 km) |
| Roanoke to Vacaville (California) | 2,274.10 mi (3,659.81 km) |
| Roanoke to Vadnais Heights (Minnesota) | 866.63 mi (1,394.70 km) |
| Roanoke to Vail (Arizona) | 1,776.11 mi (2,858.38 km) |
| Roanoke to Valdosta (Georgia) | 483.02 mi (777.34 km) |
